Corticobasal Degeneration

Corticobasal Degeneration (CBD) and progressive supranuclear palsy (PSP) are Parkinson’s-plus syndromes, meaning that they are diseases that share some of the symptoms of Parkinson's Disease such as slowing of movements, stiffness, tremors, falls, and shuffling of the feet. They may both also cause changes in memory and thinking.

People with PSP also develop problems moving their eyes, called supranuclear palsy, a wide-eyed appearance, and difficulty swallowing. Unlike Parkinson’s disease, people often fall backward instead of forward. They may also develop severe stiffness in the neck.

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There are several variations on the name of CBD, such as corticobasal syndrome or disease and corticobasal ganglionic degeneration. It is named after the parts of the brain that are damaged: the cortex (the outer part of the brain) and the basal ganglia (deep within the brain). Like Parkinson’s disease, slowing of movements, stiffness, tremors, falls and shuffling of the feet are seen. Problems with movements occur on one side of the body, such as stiffness, shaking, or loss of control. People with CBD may be unable to get their arms to do what they want even if they have the know-how. Sometimes, the arm on that side might move on its own, called alien limb syndrome.

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